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Heres how we explain microdosing GLP 1s to our patients. , Microdosing is often used for weight maintenance after proper GLP 1 GIP treatment or for patients seeking benefits beyond weight loss, Does Retatrutide Hurt? Injection Pain Guide (2026) Managing Side Effects of GLP 1 Receptor Agonist for Weight Loss: A Comprehensive Guide by Ocean Pacific Integrative Health Center Ocean Pacific Integrative Health Center The widespread adoption of glucagon like peptide 1 receptor agonists in the management of obesity and its implications for the anaesthesiologist and intensivist: A narrative review Practical Evidence in Anaesthesia Knowledge Triple hormone receptor agonist retatrutide for metabolic dysfunction associated steatotic liver disease: a randomized phase 2a trial Nature Medicine
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4.7 ★★★★★
Based on 1425 reviews
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Product Reviews
★★★★★ 4
Decent, but could easily be the industry leader by giving it all the MX Master 2S features
Style: Right-Handed, Pattern Name: Mouse, Color: Off White, Style: Right-Handed, Pattern Name: Mouse, Color: Off White
I'm rewriting my review because I "like" this product, I need it from a health standpoint and I would like to see it get better.
The one major flaw: I'm coming from the MX Master 2S, probably the best mouse I ever had. If you applied the buttons and scroll wheels from the 2S to this mouse, it would be so perfect the universe might collapse in on itself.
The big one for me as a designer is the lack of the left thumb horizontal scroll wheel, this is crucial especially in 3D programs. I also miss the ability to switch between a ratcheting feel or a smooth feel on the main wheel, not to mention the speed when I need to scroll to the top of something in an instant.
No Bluetooth: I actually originally intended to return this mouse simply based on the fact that there is no Bluetooth, it's an old USB which is SUPER annoying because Mac M2 Laptops don't even have those ports anymore, I have to connect with an adapter!
Button Layout: Not bad, but very minimal effort, like they went the cheap route because they don't believe in the product. Logitech really needs to put some real thought into these because there are some real opportunities for innovation. The button layout works, it's just not very noteworthy. Yes you might occasionally get some accidental clicks, but it's not as bad as some people say.
Size: Nearly perfect. I have average size male hands probably. I could see some work on more natural contouring to fit the hand, but this is probably the best middle ground.
Grip: Comfortable, I can rest my hand on the desk or just on the mouse with much effort. I got more or less used to the vertical feel within a week, and it's definitely helping with the wrist problems I was developing.
Build Quality: This doesn't exactly come off as cheap, but it definitely feels like it's intentionally sparse, as if Logitech is still figuring out what to do with vertical mice.
Overall this is a good mouse that will get me by for now, but it easily be the industry leader with some real investment in the tech. I really hope Logitech embraces this tech in the future, because as it stands it feels like a prototype of an afterthought.
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Reviewed in the United States on October 9, 2023
★★★★★ 3
Loved it… while it lasted
Style: Right-Handed, Pattern Name: Mouse, Color: Rose
This mouse was honestly amazing for comfort and ergonomics. I work at a desk all day, and it made a huge difference for my wrist and hand compared to a regular mouse. The vertical design felt natural pretty quickly, and I really loved using it.
The only reason I can’t give it 5 stars is because it completely stopped working after about 10 months. For the price, I expected it to last a lot longer than that. If durability was better, this would’ve easily been one of my favorite mice ever.
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Reviewed in the United States on May 16, 2026
★★★★★ 5
Bad auto driver install. Great mouse. Few of the left hand mfgs.
Style: Left-Handed, Pattern Name: Mouse, Color: Graphite
Really crappy auto driver install. Locked up my USB ports for my usb keyboard, usb mouse, all usb ports in fact. Had to reboot multiple times with an old style 5pin keyboard since the software screwed up my usb ports. All of them. Lucky I have a motherboard with an old style keyboard port. A reboot of W11 in safe mode, ripped out auto-installed software, registry keys and rebooted to regain control of my USB ports. I do not know what went wrong. Alls I know is Logitech loaded something, it locked up my USB ports and I had to rip everything Logitech out to get control again. I downloaded the software, installed it and it worked fine. I've had no problems since.
I'm an old lefty and as such am ambidextrous in most areas, since there just was not left handed oriented items readily available. You had to have left handed stuff made so you learned to do things right handed. I've developed carpal tunnel in both elbows and had purchased a couple of vertical mice, one left and one right. I took the left into work and was looking for a replacement. My other two were around $30 ea. I liked the right handed vertical mouse (Anker). They do not make a left handed version. The left handed mouse is ok, not as good as the Anker. I decided to go above my spend tolerance and get the Logi after reading many reviews. It has not disappointed me. The auto-install sucked. Never letting that happen again.
It is a nice smooth mouse. Fine movements that are easily adjustable. The hand position is excellent. I can use this all day without switching to the right because of elbow pain. If you have the pain, you know what I am talking about when it flares. It takes some getting used to the subtlety of the clicks when coming from lower cost mice. Soft and gently like a newborn's ....
One of my big criteria for a vertical mouse is a landing area for the outer two fingers (pinky and next to pinky for finger orientation challenged). When you go to a vertical mouse, it takes some adjustment to moving the mouse since you can't really press down with your palm and inside two fingers (the ones next to the outside two fingers). It is helpful to be able to use the two outer fingers and thumb to aid in moving the mouse. You have to experience a vertical mouse to understand. The right handed only Anker goes from an inch to a half inch in the length of my pinky below the buttons on the side. This is a really nice landing area for the outside fingers to assist moving the mouse around. You can squeeze a little and the mouse glides. The Logi mouse is a wee shorter than the Anker and the area below the buttons in a mostly straight 3/4". Both mice curve quickly down to the inside below this area. I was used to a vertical mouse by the time I purchased the Logi and I have no issues with the pinky dragging the table and the finger next to pinky resting on the landing. I move the mouse with no problems. It is the subtlety of how one interacts with these style of mice. The big plus, takes a long time before mouse use causes pain flareups. And this isn't just a pain and done. Depending on how one ignores the pain, often determines how many days life sucks. The Logi mouse minimizes the flare ups. I'm thinking of taking the Anker in and getting a right handed Logi for home. I like the Anker, I'm frugal and highly recommend it for getting your feet wet. I love the Logi (auto-install sucks) and will probably ignore my frugal tendencies and get a right handed one since I don't switch hands as frequently with the Logi in the mix. Don't have to suffer auto-install either.
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Reviewed in the United States on February 29, 2024
★★★★★ 4
Shape can be a game changer to reduce arm/wrist pain
Style: Right-Handed, Pattern Name: Mouse, Color: Graphite
Very easy to setup with PC, whether by bluetooth, usb, wifi. It does take some time to get used to the new design. The scrolling is very good and all functions are extremely responsive. So far, it is not causing any strain to my arm and wrist which is why I am trying this design as my older, normal shaped mouse, was causing me arm pain. They should include a quick easy to understand information sheet about the buttons. Need to download in order to customize 2 other buttons. All in all, so far I like it and definitely suggest it for people having arm or wrist pain from the angle and position of a regular shaped mouse.
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Reviewed in the United States on May 11, 2026
★★★★★ 5
Wonderful!!
Style: Right-Handed, Pattern Name: Mouse, Color: Graphite
Update -
After using this mouse for over a year I started experiencing something profoundly annoying. When dragging something from one place to another (often from monitor to monitor) I would accidentally hit one of the buttons by the thumb and it would close whatever I was working on. Especially during work where I do this often. I found there is an option to turn these buttons off in the software!!! Wonderful!!!
That was the absolute only thing I was having an issue with. Longevity has been perfect and I'll confess, I'm not particularly regular about cleaning it. I would buy this mouse again in a heartbeat.
I bought this at the same time (Feb '25) as the Logitech Ergo K860 Wireless Ergonomic Keyboard - Split Keyboard, for which I have also written a review.
I cannot say enough good things about both of these products. My neck, shoulders and back feel so much better than with my previous setup.
At the time of purchase, there were a number of reviews saying these failed fairly quickly. This has not been my experience and I am not very conscientious about cleaning it.
After almost a year of heavy use (8-10 hrs a day), the batteries are at 30% which I don't think I can complain about.
These products are not cheap, but for me they have been worth every penny and I cannot see myself going back. I'd buy them again in a heartbeat.
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Reviewed in the United States on January 28, 2026
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